British Columbia Drug and Poison Information Centre (BC DPIC)

As GLP-1 medications change American bodies and attitudes about weight, a West Virginia University fashion expert says their influence could reach all the way from consumers' closets to designers' drawing boards and retailers' racks.

Late-life semaglutide treatment slowed age-related physiological decline, attenuated multiple molecular hallmarks of aging, and extended median lifespan from 742 to 834 days in aged female mice. The drug reproduced many effects of calorie restriction while providing additional benefits in exploratory behavior, spatial memory, and glucose control, suggesting that some effects extend beyond reduced calorie intake alone.

A National Institutes of Health (NIH)-funded study has shown that the GLP-1 drug semaglutide extended lifespan in older, healthy mice by tempering the detrimental effects of aging.